Enzyme inhibition and antibacterial potential of 4-Hydroxycoumarin derivatives
نویسندگان
چکیده
منابع مشابه
The synthesis and antimicrobial activity of some 4-hydroxycoumarin derivatives.
Due to exceptional reactivity of 4-hydroxycoumarin, the synthesis of new coumarin derivatives of dimer and tetramer type has been carried out. The synthesis was carried out from 4-hydroxycoumarin and various aromatic aldehydes. In this way, compounds of the dimer 3,3'-(benzilidene)bis (4-hydroxycoumarin) type, as well as of the tetramer 3,3',3'',3'''-(1,4-dimethylenphenyl)tetra (4-hydroxycoumar...
متن کاملA Facile Synthesis of 4-Hydroxycoumarin and 4-Hydroxy-2-quinolone Derivatives
Coumarin derivatives possessing diverse biological activities play important roles as versatile building blocks for the synthesis of natural products and biologically active compounds. In particular, 4-hydroxycoumarin derivatives, such as 4-hydroxycoumarin and 4-hydroxythiocoumarin, have been used as useful intermediates for the synthesis of anticoagulants, herbicides, and anticancer agents. Re...
متن کاملAntiviral activity of some hydroxycoumarin derivatives.
Esculetin (6,7-dihydroxycoumarin) and its diacetate exhibited a marked inhibitory effect on Newcastle disease virus replication in cell cultures at concentrations of 36 microM and 62 microM, respectively. These compounds were selected from ten hydroxycoumarin derivatives through an in vitro antiviral screen involving viruses of the picorna-, orthomyxo-, paramyxo-, and herpes virus families.
متن کاملAn efficient synthesis of α,α'-benzylidene bis(4-hydroxycoumarin) derivatives catalyzed by Tl2O3 nanoparticles
In this work, we attempted to synthesize thallium (III) oxide nano structures by direct thermal decomposition using thallium I phenylsuccinic acid coordination polymer [Tl(PsucH)]n as a precursor. Also, Tl2O3 nanoparticles have been characterized by scanning electron microscopy (SEM), X-Ray powder diffraction (XRD) and IR spectroscopy and then we report a simple and efficient method for the syn...
متن کاملEnzyme inhibition, antioxidant and antibacterial potential of vasicine isolated from Adhatoda vasica Nees.
Vasicine (1) was isolated from the ethanolic extract of Adhatoda vasica Nees (Acanthaceae) and the structure was confirmed using spectroscopic techniques. Acetylcholine esterase, trypsin, DPPH inhibition potential and FRAP assay were carried out using in vitro models. The results showed 38.4 ± 1.2% and 37.4 ± 1.1% activity in acetylcholine and trypsin inhibition assays respectively. The compoun...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Brazilian Journal of Pharmaceutical Sciences
سال: 2020
ISSN: 2175-9790
DOI: 10.1590/s2175-97902019000418654